I built a Threadripper 3960X system with 24 cores, 48 threads, a little over a year ago. MOBO (ROG Zenith II Extreme Alpha) has 8 RAM slots on the mobo, each can take up to a 32 GB DIMM. But unfortunately, the AIO cooler I bought for it kind of blocks two of the 8 slots (nearest slot on each side of the cpu). So I have 6 slots * 32 GB = 192 GB of RAM. And quite frankly, I love it. Most modern OSes will utilize all of that RAM as disk cache unless and until it needs to release some for application usage. So basically, after bootup, your drives will only need to read a hard drive block once until next reboot, unless RAM gets low, or you are doing something on the machine that necessitates reading MORE than 192 GB of drive data between reboots. Subsequent reads of that same block will come straight from RAM, rather than asking the HD for it. If/when memory fills with disk cache, most OSes will keep track of which blocks of data are more in demand, and will flush the drive data of blocks that are less frequently requested. Long story short, your drives will last much MUCH longer with lots of free RAM. But as soon as you reboot the machine, it has to start back over caching everything again. So it's best to avoid unnecessary reboots.