Yes, there is some evidence that psilocybin could work as a therapeutic agent in the context of so-called treatment-resistant depression, which is observed in 10 to 30 percent of people suffering from depression. According to early studies, psilocybin is able to markedly increase depression scores with only one or two moderate to high doses having lasting effects. Also, psilocybin administered in conjunction with therapy can, at least in some studies, be effective against alcohol and cigarette dependence, reportedly reducing consumption and increasing abstinences. Nevertheless, these results can be considered preliminary only and need further exploration.